Side-chain flexibility in protein-ligand binding: The minimal rotation hypothesis
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چکیده
منابع مشابه
Side-chain flexibility in protein-ligand binding: the minimal rotation hypothesis.
The goal of this work is to learn from nature about the magnitudes of side-chain motions that occur when proteins bind small organic molecules, and model these motions to improve the prediction of protein-ligand complexes. Following analysis of protein side-chain motions upon ligand binding in 63 complexes, we tested the ability of the docking tool SLIDE to model these motions without being res...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2005
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.041153605